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Retinoids and Reproduction

Salil Kumar Mandal, Sandip Ghosh , and Chittaranjan Maity

Retinoids are essential for reproduction. Rats maintained on a diet deficient in retinol but containing instead retinoic acid grow well and outwardly healthy. But they lose the vision and ability to reproduce. The rats with vitamin A deficiency have lowered testosterone levels which can be restored by retinoic acid. Again retinoic acid cannot restore germinal epithelium of the seminiferous tubules in Vitamin A deficient rats. The action of retinoic acid is required for the commitment of germ cells to enter meiosis in both mammalian males and females