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Clumping of the Nuclei Material of Pyramidal Cells of Adult Wistar Rats Following Oral Administration of Monosodium GlutamateClumping of the Nuclei Material of Pyramidal Cells of Adult Wistar Rats Following Oral Administration of Monosodium Glutamate

Musa MA, and Sunday AM

Monosodium Glutamate (MSG) is the crystalline sodium salt of glutamate used primarily to preserve or enhance the flavor of food. Studies have shown that MSG causes damage in brain cells of animals like rats and rabbits. This research was conducted to investigate the effect of MSG on the histology of the pyramidal cells of the cerebral cortex (frontal lobe) of Wistar rats. A total of 15 adult Wistar rats were procured. The animals were divided into three (3) groups A, B and C with each group comprising of 5 animals. Group A – (the control group) was administered with 1ml of distilled water while experimental groups B and C were orally administered with 2mls and 3mls of 2g/10ml MSG for a period of 14 days. After which the rats were sacrificed and the tissues were processed using the routine histological procedures and stained with H&E method. Histological findings revealed clumping and elongation of the nuclei material of pyramidal cells in the frontal lobe of the experimental groups, with higher clumping and elongation observed in group C which was administered higher dose of monosodium glutamate.