Zhu Ming, Xueji Liu, Yali Yan, Guangchang Pang, Qingsen Chen
??????????: ???????????? ???????? (????) ???? ???????? ?? ??????????? ?????? ?????????????????????? (?????????) ??????????? ????? ???????? . ???????: BALB/c ?????? ??? ?????? ????????????? ????, ??? ?????? ????, CGMP ????????? ??????? ??????? (5 mg/kg·d), ??????? ??????? (50 mg/kg·d) ??????? ???? ??????? (500 mg/ kg·d), ??????? ??? Sulfasalazine (SASP) ????. ?????? ??????????????? ???????? ????, UC ?????????? ????????????? ??????? ???????????? Oxazolone (OXZ) ????? ???????????? ????? ???????? ??????????????. ?????? ?????????, ?????? ??????????????? ???? ??????? ???????? ???????? ???? ?????? ????????? 7 ??????????? ?? ???? ???????????? ?????????????????????, ??? ?????? ??????? ?? ??????????? ???????? ?????????? ??????????? ??? ?????? ????????????? (?????) ??????? ?????? ????? ????????? ?????????????. ??? ??????. ??????: CGMP ???? UC ???? ???????? ???? ??????????? ?? ??????????? ???? ?????????? ??????????????? ???????? ???????? ??????? ??????? ???????? ?????????? ??????????? ????????? ?????????? ????????. 50 mg/kg·d ???? ?????? ???? CGMP ???? Enterobacteriaceae ??????? Enterococci ??????????? ??????????? ????????? ????????, ??????? Bifidobacteria, Lactobacilli, Bacteroides ??????? Clostridium coccoides ??????????? ??????????? ?????????????.