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Advances in the Host Antiviral CCCH-Zinc Finger Proteins

Min Li and Wei Xu

Recognition and degradation of viral RNA are essential for antiviral innate immune responses. Zinc-finger proteins (ZFPs) are gaining intensive concern because they are attractive targets for the control of multiple cellular processes. In this short commentary, we focus on the two popular host antiviral ZFPs, zinc antiviral protein (ZAP) and monocyte chemotactic protein-induced protein 1 (MCPIP1), and discuss their antiviral effects, mechanisms and prospects