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DNAzyme-Based Biosensors for the Determination of Metal Ions Using Nanomaterials

Zhuangqun Liao and Jiahao Huang

Metal ions play significant roles in biological and environmental systems, which have thus urged scientists to develop reliable methods for the sensitive and selective detection of metal ions. The past decade has witnessed great progress in the development of metal ion sensors based on both DNAzymes (with excellent recognition selectivity towards metal ions) and nanomaterials (with unique properties to improve the detection sensitivity). This review introduces the functions and applications of nanomaterials in the DNAzymesbased metal ion sensing platforms, including gold nanoparticles (GNPs) and graphene oxides (GOs). Besides, the existing limitations and emerging trends in the area are also discussed.