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Advances in Novel Drug Delivery Strategies for Targeting Brain Tumors: An Insight

Aman Mishra, Priyanka Bajpai*, Om Prakash

The development of a drug delivery strategy that can not only cross the Blood Brain Barrier (BBB) rapidly but also target the glioma and reach the core of the glioma is essential and important for glioma treatment. A targeted drug delivery system is a unique approach for drug delivery to the appropriate site which is highly efficient, biocompatible and non-immunogenic. Receptor-mediated endocytosis is one of the targeting approaches, especially for targeting anticancer drugs to cancerous sites. In the brain, cancer cells have overexpressed receptors like folate, transferrin, low-density lipoprotein, and hyaluronic acid receptors which can be used for effective site-specific drug delivery to cancerous cells using appropriate receptor-specific ligands. Active and passive targeting promotes tumor specificity with reduced possible side effects. Several nanocarriers like liposomes, nanoparticles, micelles, and dendrimers are used in the delivery of drugs to the target site. There is many transporter also involves in targeting. Targeted drug delivery systems have numerous clinical and diagnostic applications. Modern approaches like ligand-mediated or stimuli-sensitive drug delivery systems have been used for the development of multifunctional nanocarriers that can effectively target cells and cellular organelles.