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Transdermal Drug Delivery - Advancement to Reduce Side Effects of Drugs

Pratibha Muntha

The advancement in the field of formulation pharmaceutics lead to the discovery of many advanced dosage forms that aid in maintaining desired levels of active substance at the predetermined target site with a release rate desired to treat the diseases in the patient. Transdermal drug delivery is one such advancement as a good alternative to conventional pharmaceutical dosage form Transdermal drug delivery has several advantages over conventional dosage forms of avoiding first pass metabolism with increased patient compliance maintaining the release of the drug at a constant rate in a controlled fashion which is advantageous for drugs with narrow therapeutic window resulting in reduced side effects of the drugs It is not suitable for high molecular weight compounds as it becomes difficult to prepare the formulation and even not suitable for water soluble drugs