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Synthesis of Some Newer Nalidixic Acid Derivatives as Potent Antimicrobial Agents

Fathi H Assaleh, Babu Rao Chandu, Ramalingam Peraman and Prakash Katakam

A molecular manipulation efforts were made at β carbon of α, β unsaturated site of nalidixic acid by Michael addition, in expectation to get newer chemimanipulated derivatives with potent/modified antimicrobial spectrum. At the ends of chemimanipulative work, totally 5 derivatives were synthesized and characterized by spectral data. All the derivatives were screened for its antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aureginosa, and Proteus vulgaris at a concentration of 100μg/disc with the same dose of nalidixic acid as control by agar plate disc diffusion method. The results revealed that hydrazine substituted tricyclic derivatives exhibited potent antibacterial activity gram +ve rather than against gram –ve, however, potentiation were found to be against gram +ve and gram –ve bacteria.