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Synthesis of Novel 2H-Pyrano[2,3-D]Thiazole-6-Carbonitrile Derivatives in Aqueous Medium

Shelke RN, Pansare DN, Pawar CD, Shinde DB, Thore SN, Pawar RP and Bembalkar SR

A one-pot efficient, green and environmentally friendly multicomponent synthesis of novel 5-amino-7-(substituted phenyl)-2-thioxo- 3,7-dihydro-2H-pyrano[2,3-d]thiazole-6-carbonitrile derivative in the presence of green, low cost, mild, efficient and commercially available potassium carbonate as the catalyst with water. This method has the advantages of high yield, simple, clean reaction, short reaction time and no use of hazardous organic solvents.