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Synthesis, Characterization and Biological Studies of Novel 1,3,4-Oxadiazole Derivatives

Darshansinh AR, Acharya GD and Govindkumar RV

Naphtho[2,1-b]furan-2-carbohydrazide (2) prepared from reaction between ethyl naphtho[2,1-b]furan-2-carboxylate (1) and hydrazine hydrate, then compound (2) on reaction with CS2/KOH gives 5-(naphtho[2,1-b] furan-2-yl)-1,3,4-oxadiazole-2(3H)-thione (3), Which on mannich reaction followed by reaction with benzoic hydrazine gives different N-(1- ((dialkylamino)methyl)-3-(naphtho[2,1-b]furan-2-yl)-5-thioxo-1H-1,2,4- triazol-4(5H)-yl)benzamide (4a-e). With the help of analytical and spectral data, the structure of these compounds were detected. Antibacterial and antifungal activities of the synthesized compounds were studied