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Synthesis and Biological Evaluation of New 2-(5-fluoro-2-methyl-lH-inden-3-yl) Acetohydrazide Derivatives

R. B. Kawde, D. V. Patil, J. K. Patil and V. D. Jadhav

Compound 2-(5-fluoro-2-methyl-1H-inden-3-yl) acetohydrazide was reacted with various substituted aldehydes at elevated temperature in methanol to yield substituted N-benzylidene-2-(2-methyl-1H-inden-3-yl) acetohydrazide as sole product. It is also observed that reaction went to completion during 8-10 hrs at reflux condition without adding any acid or base catalyst. The reaction condition found general for all the substituted benzaldehyde. These derivatives are found more than 80% in yield. These new compounds are studied for the antimicrobial activity.