Xiu Jie Liu*, Chao Qing Wang, Xiao Wang, Qing Xiang Zhang , Kai Liu
On the principles of isosterism and for the new antiplatelet aggregating drug purposes, nineteen N,N’-di(3-substitutedphenyl)-4-methoxylbenzene-1,3-disulfonamides of series 2 were synthesized by two steps of reactions including chlorosulfonation and ammonolysis. There in vitro anti-platelet aggregation activities were evaluated by Born test and in comparison with their structure analogues of 4-methoxyisophthalamides of series 1. Results among the series 2 screened, compound 4n has the highest activity and 7 compounds (4b, 4d, 4g, 4h, 4j, 4n and 3h) have higher activities than that of the control drugs both Picotamide and Aspirin.