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Synthesis and Antimicrobial Activity of new (Z)-2-((5-(4-Hydroxybenzylidene)-4-Oxo-4,5 Dihydrothiazol-2-Yl)Amino) Acid and its Derivatives

Pansare Dattatraya N and Shinde Devanand B

A series of (Z)-2-((5-(4-hydroxybenzylidene)-4-oxo-4,5-dihydrothiazol- 2-yl)amino) acid and its derivatives were synthesized from appropriate 2-thioxothiazolidin-4-one using nucleophilic substitution and Knoevenagel condensation. All compounds have been synthesized, characterized and screened for their antimicrobial activity against gram positive bacteria and gram negative bacteria along with Ampicillin and Ciprofloxacin as standard drug. According to results obtained all compound shows good to moderate activity against all strain tested, compatible to Ampicillin but lower than Ciprofloxacin. Amongst these compounds (6c) shows very good and moderate activity as compare to standards drugs against Gram positive bacteria B. subtilus and S. aureus. Some of the most potent compounds, namely (6b, 6h and 6j) possessed selectively antimicrobial activity.