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Recalcitrant Proliferative Verrucous Hyperplasia of Palate Transforming Into Squamous Cell Carcinoma: A Diagnostic Emergency.

Kotyanaik Maloth, Naga Jyothi Meka, Srikanth Kodangal, and Mithare Sangmesh

Proliferative verrucous leukoplakia (PVL) is a rare and specific variant of oral leukoplakia, different from oral verrucous leukoplakia, principally characterized by chronic proliferation, multiple occurrences, and refractoriness to treatment. Its rate of malignant transformation is extremely high. The aggressive and malignant behavior of Proliferative verrucous leukoplakia sometimes is masqueraded by atypical clinical presentation which can be eliminated by specific diagnostic criteria enlisted by the authors after extensive research. This paper report a case of Proliferative verrucous leukoplakia involving palate with a tendency of rapid transformation towards squamous cell carcinoma clinic-pathologically, emphasizing that all leukoplakia lesions should be closely monitored, even those that initially present nonaggressive behavior.