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Preventive effect of Ziziphus nummularia Burm on Cardiac Markers in Normal and Isoproterenol induced Myocardial Necrosis in Rats

Appalarowthu Tejaswi

Myocardial infarction is making an increasingly important contribution to mortality statistics of Cardiovascular diseases. The present study was aimed to investigate the cardioprotective effect of fruits of Ziziphus nummularia in isoproterenol induced myocardial infarcted rats. Subcutaneous injection of isoproterenol (150 mg kg-1) to rats at an interval of 24 h for 2 days showed a significant (p<0.001) increase in cardiac marker enzymes (LDH, CKMB, SGOT and SGPT). Pre-treatment with Ziziphus nummularia to isoproterenol treated rats for a period of 42 days showed significant (p<0.001) cardioprotective effect. Administrations of Ziziphus nummularia to normal rats have shown very less significant effect on above parameters. So, the study revealed that the cardioprotective effect of Ziziphus nummularia in isoproterenol induced myocardial infarction may be due to decrease in the levels of cardiac markers, which was further confirmed by histopathological studies.