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NEWER ROUTE FOR THE SYNTHESIS OF N-PYRAZOLYLCARBOXASULFONAMIDES

Shivdas Bajod, Namdeo Chavhan ,Vijaykumar Markad, Kisan Kodam, Jagrut Waghmare and Sharad Shelke

In this study the investigations on the synthesis of N-Acyl Sulfonamide derivatives of pyrazole nucleus are reported. Ethyl-3-pyrazole carboxylate 1 has been used as starting material and it treated with aryl boronic acid in cupric acetate and DMF as a solvent afford N-aryl ethyl-3-pyrazole carboxylate 2 followed by alkaline hydrolysis to get N-aryl ethyl-3-pyrazole carboxylic acid 3. When compound 3 stirred with aryl sulfonylamide in the presence of DCC, DMAP in DCM affords N-pyrazolylcarboxasulfonamides4.