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New Validated Spectroscopic Method for the Simultaneous Estimation of Simvastatin and Sitagliptin.

Sujani PV, Y Padamanabha Reddy, N Devanna, SS Phanindra, and P Anasuya

A new, simple, sensitive, rapid, economic, UV Spectroscopic method was developed for the estimation of Simvastatin-Sitagliptin in Pure and Tablet dosage forms. The differences in solubilities of drugs were used for the estimation by extracting them into individual solvents. The linearity for Simvastatin was found between 6-20 μg/ml and between 10-50 μg/ml for Sitagliptin. Simvastatin showed the maximum absorbance at 232nm & Sitagliptin at 246nm and Validation parameters like Precision, Accuracy, and System suitability parameters were determined and examined by applying validated parameters.