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In-Vitro Drug Release Studies Of Insulin Loaded Eudrajit L Microspheres

Sanjay R Patel, and Vipul P Patel

The speculation of this research was to observe whether Eudrajit L microspheres have the potential to serve as an oral carrier for peptide drugs like insulin. Eudragit L-100 based Insulin loaded Microspheres were prepared by quasi-emulsion solvent diffusion method with polysorbate 20 as dispersing agent in the internal aqueous phase (IAP) and PVA/PVP as stabilizer in the external aqueous phase. The production yield was found to be between 61-79% for PS1-PS4. In the first hour drug release of different Microsphere formulations SP1- SP4 was noted to be 19-29%. This may be attributed to the drug present in the pores of the Microspheres. The overall cumulative percent release for different Microsphere formulations PS1-PS4 at the end of eight hours was found to be 56-86 %.