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Formulation of Small Size Gold Nano-particles Stabilized with Novel Polyethylene Glycol (PEG)-N-Acetyl Cysteine (NAC) Conjugate

Ayoub AH, Safadi N, Inibtawi M and Shadafny S

Background: Gold nano particles demonstrate size-related properties; their photonic and catalytic properties were found to be very attractive for materials applications as well as biomedical/biochemical. Methods to synthesis gold nano-particles were reported in previous studies, however, formation of uniform small gold nano particles and stabilizing these GNPs at protein containing solution is still challenging. Therefore, the main objective of this study is to develop a new simple and reproducible method to synthesize small gold nano particles and to stabilize them at protein containing solutions for possible medical uses such cancer imaging and therapy.

Results: We synthesized small gold nano particles with average diameter of ~ 3.5 nm as well we developed and synthesized a PEG–NAC conjugate to stabilize the GNPs at protein containing solutions.

Conclusions: Our new method to synthesize GNPs is successful and reproducible, further the new PEG-NAC conjugate that we developed is capable of binding the surface of the gold nano-particles and provides the GNPs enhanced solubility and improved stability particularly at protein containing solutions.