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Formulation and Evaluation of Dicloxacillin Sodium Floating Tablets.

Murari Pavan, Prasanth VV, Abhishek Sharma, Ajay Chauhan, Rinku Mathappan, and Sam T Mathew

The purpose of this research work was to develop gastroretentive drug delivery system of Dicloxacillin sodium. Floating tablets were prepared by wet granulation method using gas generating agents such as sodium bicarbonate and citric acid anhydrous, like Hydroxypropyl methylcellulose (HPMC K100M), Xanthan gum, Sodiumcarboxy methylcellulose (NaCMC) and Microcrystalline cellulose (MCC). Dicloxacillin sodium floating tablets were prepared by wet granulation method were found to be good without chipping, capping and sticking. The drug content was uniform in all the tablet formulations indicating uniform distribution of drug within the matrices. All the prepared batches showed satisfactory floating lag time and total floating time found to be more than 12 h. Formulation F14 showed desired drug release selected as a best formulation and subjected to stability studies for 3 months showed that formulation is intact without interaction. Finally optimized formulation F14 complying with all properties of floating tablets and found to be satisfactory.