K Vanitha Prakash, Ravi Pratap Pulla and Y Kranthi Kumar
A simple, accurate and sensitive liquid chromatographic method has been developed for the determination of Rasagiline Tartrate (RAST) in API and its dosage forms. The separation was achieved on Inertsil ODS (250mm X 4.6mm) C18, 5 μm column. The mobile phase consisted of Methanol: Acetonitrile: Water (50:30:20 v/v), pH: 3.2 adjusted with Triethylamine (TEA), flow rate 1 mL/min at ambient temperature. The analytes were monitored by PDA detector at 206 nm. The method was validated for specificity, precision, linearity, and accuracy. The average recoveries for RAST were in the range of 89.0 – 93.0% and the present work has been focused on the development of simple, accurate and precise analytical method based on RP-HPLC for the formulation of RAST.
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