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Analytical Methodologies for the Determination of Hydralazine: A Review.

Shah Kruti V, Chauhan SP, and Suhagia BN

Hydralazine belongs to the hydrazinophthalazine class of drugs and it is a potent vasodilator, which is used in combination with a suitable β-blocking drug to treat hypertension. Hydralazine is not only a peripheral vasodilator but also a potent and irreversible inhibitor of Semicarbazide sensitive amine oxidase (SSAO). It was sold under the brand name Apresoline® by Novartis and approved by the U.S. Food and Drug Administration (FDA) in 1953. A widespread review of the literature published in various pharmaceutical journals has been conducted and the instrumental analytical methods which are developed and used for determination of Hydralazine have been reviewed. This review includes Potentiometric titration, Colorimetric method, HPLC-UV, HPLC with Electrochemical detection, HPLC-MS/MS, GC-ECD, GC-FID and GC-NSD. The applications of these methods for the determination of Hydralazine in pharmaceutical formulations and biological sample have also been discussed in this article.