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A Clinical Study on C - Reactive Protein in Periodontal Diseases: Systemic Inflammatory Relationship.

Rajiv Saini

Periodontitis is associated with elevated levels of systemic inflammatory biomarker C-reactive protein (CRP). This study is outlined to determine and correlate the C-reactive protein level in health, gingivitis and periodontitis and to assess the CRP values after complete scaling and root planning. Sixty systemically healthy subjects enrolled in the study. Twenty subjects each categorized under three group’s i.e. periodontally healthy, gingivitis and periodontitis. Clinical parameters and serum CRP is recorded at the baseline, 15th and 30th day. Patients with chronic periodontitis had statistically significant elevations in serum C- reactive protein levels as compared to gingivitis and absence of detection of serum CRP level in health group. Results showed a highly significant change in clinical parameters and serum CRP with regard to improvement in the gingival inflammation and reduced bleeding on probing and plaque accumulation from the baseline when compared to the 15th day and 30th day. A correlation exists between the periodontal disease and CRP, as the periodontal disease regresses the value of CRP lowers down significantly. Non-surgical periodontal treatment i.e. scaling and root planing was effective in reducing the levels of serum C - reactive protein.